biomarkers

Postural sway correlates with cognition and quality of life in Parkinson’s disease

We measured postural sway in individuals diagnosed with Parkinson's disease and age-matched controls. Individuals with Parkinson's swayed more, as expected, especially when their eyes were closed. In the people with Parkinson's, sway correlated strongly with cognitive measures, as well as with measures of quality of life and clinical status.

Which features of postural sway are effective in distinguishing Parkinson's disease from controls? A systematic review

Background: Postural sway may be useful as an objective measure of Parkinson's disease (PD). Existing studies have analyzed many different features of sway using different experimental paradigms. We aimed to determine what features have been used to …

Robust feature engineering for Parkinson disease diagnosis: New machine learning techniques

Background: Parkinson disease (PD) is a common neurodegenerative disorder that affects between 7 and 10 million people worldwide. No objective test for PD currently exists, and studies suggest misdiagnosis rates of up to 34%. Machine learning (ML) …

Cerebellar–cortical dysconnectivity in resting‐state associated with sensorimotor tasks in schizophrenia

Abnormalities of cerebellar function have been implicated in the pathophysiology of schizophrenia. Since the cerebellum has afferent and efferent projections to diverse brain regions, abnormalities in cerebellar lobules could affect functional …

Postural sway abnormalities in schizotypal personality disorder

We measured postural sway in individuals diagnosed with schizotypal personality disorder, but otherwise free of medication and other comorbidities. They swayed significantly more than matched controls, and as much as people dignosed with schizophrenia, in all conditions.

Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE-HD study

**Background:** Huntington's disease (HD) causes progressive atrophy to the striatum, a critical node in frontostriatal circuitry. Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral …

Abnormal electrophysiological motor responses in Huntington’s disease: evidence of premanifest compensation

**Background** Huntington's disease (HD) causes progressive motor dysfunction through characteristic atrophy. Changes to neural structure begin in premanifest stages yet individuals are able to maintain a high degree of function, suggesting …

Atypical Motor Response Potentials (MRPs) in Symptomatic Huntington’s Patients During Simple Movements

## Background Huntington's Disease causes progressive motor dysfunction through atrophic disruption to the frontal cortical motor circuitry and basal ganglia regions. Symptom onset typically begins at age 40; subsequent neurodegeneration is …